View abstract. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Westman EC, Guthrie GP. Therapeutic Research Faculty 2020. View abstract. World J Gastroenterol 2-7-2006;12(5):760-764. Tewari SN, Wilson AK. Quinkler M, Stewart PM. Researchers from the University of Minnesota studied 50 atopic dogs in a randomized, double-blind, placebo-controlled trial. View abstract. View abstract. Fujisawa, Y., Sakamoto, M., Matsushita, M., Fujita, T., and Nishioka, K. Glycyrrhizin inhibits the lytic pathway of complement--possible mechanism of its anti-inflammatory effect on liver cells in viral hepatitis. View abstract. Bocker, D. and Breithardt, G. [Induction of arrhythmia by licorice abuse]. View abstract. Huang, W. W., Wang, M. Y., Shi, H. M., Peng, Y., Peng, C. S., Zhang, M., Li, Y., Lu, J., and Li, X. Braz J Infect Dis 2016;20(6):534-8. View abstract. Eur J Drug Metab Pharmacokinet. Ha Y, Wang T, Li J, et al. 2013 Nov;18(6):593-6. This might decrease the effects of midazolam. Monitor your blood pressure closely. Schleimer, R. P. Potential regulation of inflammation in the lung by local metabolism of hydrocortisone. Information from this source is evidence-based and objective, and without commercial influence. Low potassium levels can increase the side effects of digoxin. View abstract. One major reported side effect of licorice root is reduced levels of testosterone in men ( 10 ). View abstract. Li J, Fan X, Wang Q. Hypertensive crisis with 2 target organ impairment induced by glycyrrhizin: a case report. Anesth Analg 2009;109(1):77-81. View abstract. A., Keller, W. J., Pereira, M. A., and Kinghorn, A. D. Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). J Clin Pharm Ther 2001;26:271-8. Read more. What are the side-effects of taking liquorice? Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats. Ital.J Neurol.Sci 1997;18(4):217-220. Be sure to have your blood checked regularly. Nahidi F, Zare E, Mojab F, Alavi-Majd H. Effects of licorice on relief and recurrence of menopausal hot flashes. 1991;4(2):166-173. Zhang XH, Lowe D, Giles P, et al. Clin Pharmacol Ther 1996;59:62-71. Gibertoni, M., Bonito, V., Colombo, A., Falasca, A., and Nichelli, P. [Licorice-induced myopathy. A 2020 review found that licorice root extract can help reduce the growth of . Clin Neurol Neurosurg 2003;105:286-7.. View abstract. Yamashiki, M., Nishimura, A., Suzuki, H., Sakaguchi, S., and Kosaka, Y. Ruetzler K, Fleck M, Nabecker S, Pinter K, Landskron G, Lassnigg A, You J, Sessler DI. Jin, C. Y., Wang, D. L., and Fang, Z. D. [Effect of integrative Chinese and Western medicine in treating chronic urticaria and its impact on interleukin-10 and interleukin-8 in peripheral blood]. View abstract. [Clinical observation on auxiliary treatment of hormone dependence dermatitis by shufeng liangxue decoction]. View abstract. Wang Y, Ma R. [Effect of an extract of Paeonia lactiflora on the blood coagulative and fibrinolytic enzymes]. Licorice might decrease the effects of warfarin. The author has contributed to research in topic(s): Rheum officinale. View abstract. View abstract. van der Zwan A. View abstract. J Nutr Sci Vitaminol. Pfeifer BL, Pirani JF, Hamann SR, Klippel KF. de Klerk GJ, Nieuwenhuis G, Beutler JJ. Am J Med Sci 2003;325:153-6. View abstract. Mechanisms by which Hange-shashin-to reduces prostaglandin E2 levels. Wu, T. H., Chiu, T. Y., Tsai, J. S., Chen, C. Y., Chen, L. C., and Yang, L. L. Effectiveness of Taiwanese traditional herbal diet for pain management in terminal cancer patients. People who regularly take large amounts of licorice, more than 20 g/day, may raise blood levels of the hormone aldosterone, which can cause serious side effects, including headache, high blood pressure, and heart problems. Minerva Med 2008;99(1):91-94. Lin, J. C. Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus replication in vitro. Wang H, Dong L, Qu F, et al. This formula has also been shown to dramatically relieve various types of spasmodic pain such as muscle cramps in the back and legs (restless legs) stiff muscles premenstrual cramping sciatica and abdominal pain. Acharya SK, Dasarathy S, Tandon A, et al. View abstract. Lee, S. M., Li, M. L., Tse, Y. C., Leung, S. C., Lee, M. M., Tsui, S. K., Fung, K. P., Lee, C. Y., and Waye, M. M. Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. Ito, M., Sato, A., Hirabayashi, K., Tanabe, F., Shigeta, S., Baba, M., De Clercq, E., Nakashima, H., and Yamamoto, N. Mechanism of inhibitory effect of glycyrrhizin on replication of human immunodeficiency virus (HIV). Int Immunopharmacol. It may disrupt the production of sex hormones ( 9 ). View abstract. Melzer J, Rosch W, Reichling J, et al. Br Med J 1971;3(773):501-503. Menati L, Khaleghinezhad K, Tadayon M, Siahpoosh A. 2020;247:112226. View abstract. Yasue H, Itoh T, Mizuno Y, Harada E. Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice. WebMD does not provide medical advice, diagnosis or treatment. When eaten in large quantities, black licorice can cause serious health issues. How Much Is Too Much? This week, The New England Journal of Medicine reported that a man with a poor diet died of cardiac arrest after eating a bag-and-a-half of black licorice daily for weeks. 2014 Jun;23(3):189-92. 2003;23(8):593-595. View abstract. Am J Psychiatry 1994;151:617-8. Evid Based Complement Alternat Med 2016;2016:9852793. Kent UM, Aviram M, Rosenblat M, Hollenberg PF. Bian, X., Xu, Y., Zhu, L., Gao, P., Liu, X., Liu, S., Qian, M., Gai, M., Yang, J., and Wu, Y. View abstract. Anti Erection Pill. A pilot study. View abstract. View abstract. Some research suggests that licorice extract may help kill bacteria in the mouth that cause tooth decay. View abstract. View abstract. Pharmacol Biochem Behav 1993;45:719-23. . Iran J Pharm Res. Some medications are moved in and out of cells by pumps. Hsiu, S. L., Lin, Y. T., Wen, K. C., Hou, Y. C., and Chao, P. D. A deglucosylated metabolite of paeoniflorin of the root of Paeonia lactiflora and its pharmacokinetics in rats. Korri, H., Awada, A., Baajour, W., Beaini, M., and Nasreddine, W. [Rapidly progressing quadriparesis secondary to licorice (souss) intoxication]. Select a condition to view a list of vitamins. The dogs treated with the herbal mixture saw a 37.5 percent improvement . Chen MF, Shimada F, Kato H, Yano S, Kanaoka M. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. J Neuroophthalmol. View abstract. N Engl J Med 1990;322:849-50. It is often used together with peony, which can significantly enhance . View abstract. White Peony is technically named Peonia lactiflora, and in Chinese, it is named Bai Shao. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. View abstract. J Endocrinol Invest 1990;13(10):847-848. Zhong Xi Yi Jie He Za Zhi 1991;11:102-4, 69. J Clin Endocrinol Metab 2003;88:2384-92. Li G, Simmler C, Chen L, et al. Peony-glycyrrhiza decoction for antipsychotic-related hyperprolactinemia in women with schizophrenia: a randomized controlled trial. View abstract. Phytother Res 2008;22:563-5. Sakamoto, S., Yoshino, H., Shirahata, Y., Shimodairo, K., and Okamoto, R. Pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas. View abstract. View abstract. Antiviral Res 1987;7(2):99-107. Zhu Q, Qi X, Wu Y, Wang K. Clinical study of total glucosides of paeony for the treatment of diabetic kidney disease in patients with diabetes mellitus. View abstract. View abstract. Apparantly it's the one most important thing that shouldn't mix with Prednisolone and it makes withdrawal symptoms much worse. View abstract. mentioned adverse effects and recurrence rates. View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Caubet-Kamar, N., Tubery, M., Garrouste, C., Lauque, D., and Kamar, N. Harmful effect of saline infusion in a patient with glycyrrhizic acid poisoning. Report of 2 cases and review of the literature. J Clin Pharm Ther 2002;27:229-30. . Harada M, Suzuki M, Ozaki Y. Menopause 2002;9:145-50. View abstract. View abstract. [Clinical study on treatment of mid-advanced crescentic nephritis by qingre huoxue recipe]. Brayley J, Jones J. Life-threatening hypokalemia associated with excessive licorice ingestion (letter). May Harm Baby During Pregnancy. View abstract. View abstract. Xu, L., Jiang, J., and Du, F. Z. Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, Bensoussan A. No negative side effects. View abstract. Note: Results may vary from person to person, depending on the skin type. View abstract. Elinav E, Chajek-Shaul T. Licorice consumption causing severe hypokalemic paralysis. Mol Cell Endocrinol. View abstract. Fortschr.Med 7-30-1992;110(21):395-398. Helpful. Aldosterone is a hormone that causes your body to retain salt (sodium) and lose potassium. Teelucksingh S, Mackie AD, Burt D, McIntyre MA, Brett L, Edwards CR. Ir J Med Sci 2016;185(4):945-7. OTHER NAME(S): Acide Glycyrrhizique, Acide Glycyrrhizinique, Alca. Kormann R, Languille E, Amiot HM, Hertig A. J Tradit.Chin Med 2010;30(1):47-50. Some possible side effects with oral use include rash, itching, nasal symptoms, or stomach discomfort, but these are uncommon. 2019;35:329-41. 2013 Sep;117(3):614-21. View abstract. We currently have no information for PEONY overview. View abstract. Eriksson JW, Carlberg B, Hillom V. Life-threatening ventricular tachycardia due to liquorice-induced hypokalemia. Rosenblat, M. and Aviram, M. Paraoxonases role in the prevention of cardiovascular diseases. Radix Paeoniae Alba increases serum estrogen level and up-regulates estrogen receptor expression in uterus and vagina of immature/ovariectomized mice. Zhou Y, Jin L, Kong F, et al. Let's take a look at the forms, uses, and side effects of . Jia, Y. View abstract. View abstract. J Am Coll.Nutr 2007;26(3):209-218. Biol Pharm Bull. Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. A double-blind, randomized, placebo-controlled trial on the effects of an herbal preparation in patients with functional dyspepsia [Abstract]. Severe hypokalaemia with paralysis induced by small doses of liquorice. O'Connell, R. L., White, I. R., White, J. M., and McFadden, J. P. Liquorice extract in a cosmetic product causing contact allergy. This information may not fit your specific health circumstances. Fang, J. Y. Chen, W. G. and Ba, Z. M. Prof. ZHANG Yi's experience in treating severe arrhythmia. Patel P, Aknouk M, Dawson A, et al. Hsu, Y. L., Wu, L. Y., Hou, M. F., Tsai, E. M., Lee, J. N., Liang, H. L., Jong, Y. J., Hung, C. H., and Kuo, P. L. Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway. It might also decrease the effects of birth control pills. Scali, M., Pratesi, C., Zennaro, M. C., Zampollo, V., and Armanini, D. Pseudohyperaldosteronism from liquorice-containing laxatives. Too much black licorice, the federal agency says, can lead to "abnormal heart rhythms, as well as high blood pressure, edema (swelling), lethargy, and congestive heart failure." . Nasal irrigation with Glycyrrhiza glabra extract for treatment of allergic rhinitis - A study of in vitro, in vivo and clinical trial. J Nat Prod 1980;43(2):259-269. Zhang YD, Lorenzo B, Reidenberg MM. Acute myopathy associated with chronic licorice ingestion: reversible loss of myoadenylate deaminase activity. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. View abstract. Gomaa AA, Mohamed HS, Abd-Ellatief RB, Gomaa MA, Hammam DS. I. Elucidation of five new flavonoid constituents from the roots of Glycyrrhiza glabra L. collected in Xinjiang. View abstract. J Hum Hypertens 2001;15:549-52. View abstract. Indian J Med Res 1993;98:69-74. Br J Dermatol 1992;126:179-84. View abstract. The sweet stuff in your kids' trick-or-treat buckets may come with a bitter side effect. Shen, A. Y., Wang, T. S., Huang, M. H., Liao, C. H., Chen, S. J., and Lin, C. C. Antioxidant and antiplatelet effects of dang-gui-shao-yao-san on human blood cells. Zhong.Xi.Yi.Jie.He.Za Zhi. This might increase the effects and side effects of methotrexate. Holtmann G, Madisch A, Juergen H, et al. Pakravan F, Salehabad NH, Karimi F, Isfahani MN. View abstract. One of its most known effects is the induction of hypertension, and it can induce what appears to be pseudohyperaldosteronism, due to glycyrrhetinic acid, the main active component of the root.